Maureen E. Shetty examines representation and decision-making in U.S. breast and skin cancer trials through two studies. The first finds that men are significantly underrepresented in breast cancer trials and that minority groups are underrepresented in both cancer types. The second study surveys 306 adults, revealing that awareness, provider trust, and perceived treatment benefits increase willingness to join, while safety concerns, logistics, and costs deter participation. A modest link between patient–provider connection and willingness is also observed. The findings point to solutions such as culturally relevant outreach, more inclusive materials, transportation and financial support, and better provider engagement in discussing trials as a treatment option.
Advancing Representation in U.S. Clinical Trials: An Analysis of Intent to Participate, Participation Dynamics, Barriers, and Motivations
